1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Rosiptor acetate

Rosiptor acetate  (Synonyms: AQX-1125 acetate)

目录号: HY-109011A
产品使用指南

Rosiptor (AQX-1125) acetate 是一种选择性,具有口服活性的磷酸酶 SHIP1 激活剂,具有抗炎作用。Rosiptor acetate (AQX-1125) 在体外抑制 Akt 磷酸化、炎症介质生成和白细胞趋化。

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Rosiptor acetate Chemical Structure

Rosiptor acetate Chemical Structure

CAS No. : 782487-29-0

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Rosiptor acetate 的其他形式现货产品:

Customer Review

Other Forms of Rosiptor acetate:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rosiptor (AQX-1125) acetate is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor acetate (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].

IC50 & Target

SHIP1[1]

体外研究
(In Vitro)

Rosiptor acetate (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Rosiptor acetate (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor acetate (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

381.55

Formula

C22H39NO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Rosiptor acetate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Rosiptor acetate
目录号:
HY-109011A
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