1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Rosiptor

Rosiptor (Synonyms: AQX-1125)

目录号: HY-109011 纯度: ≥98.0%
产品使用指南

Rosiptor (AQX-1125) 是一种选择性,具有口服活性的磷酸酶 SHIP1 激活剂,具有抗炎作用。Rosiptor (AQX-1125) 在体外抑制 Akt 磷酸化、炎症介质生成和白细胞趋化。

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Rosiptor Chemical Structure

Rosiptor Chemical Structure

CAS No. : 782487-28-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥4510
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5 mg ¥4100
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10 mg ¥5900
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25 mg ¥10000
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50 mg ¥14000
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  • 生物活性

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  • 参考文献

生物活性

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].

IC50 & Target

SHIP1[1]

体外研究
(In Vitro)

Rosiptor (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation)
Concentration: 0.1, 1, 10 μM
Incubation Time: 30 minutes
Result: Induced a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it failed to affect Akt phosphorylation in Jurkat cells.
体内研究
(In Vivo)

Rosiptor (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks old male CD-1 mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: p.o.; daily for 3 days
Result: Significantly reduced the total number of BAL leukocytes in NSC-125066-challenged mice, up to a maximum of 60% at 7 days and 63% at 21 days at 30 mg/kg; Reduced MPO activity by 54% at Day 7 and by 74% at Day 21 at 30 mg/kg.
Animal Model: Male Sprague-Dawley rats[1]
Dosage: 10 mg/kg (Pharmacokinetic Study)
Administration: Oral administration
Result: The Cmax value is 0.830 μM and the t1/2 value is 5.2 hours.
Clinical Trial
分子量

321.50

Formula

C20H35NO2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 150 mg/mL (466.56 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1104 mL 15.5521 mL 31.1042 mL
5 mM 0.6221 mL 3.1104 mL 6.2208 mL
10 mM 0.3110 mL 1.5552 mL 3.1104 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献

纯度: ≥98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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Rosiptor
目录号:
HY-109011
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