1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Rosiptor

Rosiptor  (Synonyms: AQX-1125)

目录号: HY-109011 纯度: 99.35%
COA 产品使用指南

Rosiptor (AQX-1125) 是一种选择性,具有口服活性的磷酸酶 SHIP1 激活剂,具有抗炎作用。Rosiptor (AQX-1125) 在体外抑制 Akt 磷酸化、炎症介质生成和白细胞趋化。

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Rosiptor Chemical Structure

Rosiptor Chemical Structure

CAS No. : 782487-28-9

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3850
In-stock
1 mg ¥1400
In-stock
5 mg ¥3500
In-stock
10 mg ¥4900
In-stock
25 mg ¥7840
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Rosiptor:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].

IC50 & Target

SHIP1[1]

体外研究
(In Vitro)

Rosiptor (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation)
Concentration: 0.1, 1, 10 μM
Incubation Time: 30 minutes
Result: Induced a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it failed to affect Akt phosphorylation in Jurkat cells.
体内研究
(In Vivo)

Rosiptor (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks old male CD-1 mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: p.o.; daily for 3 days
Result: Significantly reduced the total number of BAL leukocytes in NSC-125066-challenged mice, up to a maximum of 60% at 7 days and 63% at 21 days at 30 mg/kg; Reduced MPO activity by 54% at Day 7 and by 74% at Day 21 at 30 mg/kg.
Animal Model: Male Sprague-Dawley rats[1]
Dosage: 10 mg/kg (Pharmacokinetic Study)
Administration: Oral administration
Result: The Cmax value is 0.830 μM and the t1/2 value is 5.2 hours.
Clinical Trial
分子量

321.50

Formula

C20H35NO2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 150 mg/mL (466.56 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1104 mL 15.5521 mL 31.1042 mL
5 mM 0.6221 mL 3.1104 mL 6.2208 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.35%

参考文献

Rosiptor 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1104 mL 15.5521 mL 31.1042 mL 77.7605 mL
5 mM 0.6221 mL 3.1104 mL 6.2208 mL 15.5521 mL
10 mM 0.3110 mL 1.5552 mL 3.1104 mL 7.7760 mL
15 mM 0.2074 mL 1.0368 mL 2.0736 mL 5.1840 mL
20 mM 0.1555 mL 0.7776 mL 1.5552 mL 3.8880 mL
25 mM 0.1244 mL 0.6221 mL 1.2442 mL 3.1104 mL
30 mM 0.1037 mL 0.5184 mL 1.0368 mL 2.5920 mL
40 mM 0.0778 mL 0.3888 mL 0.7776 mL 1.9440 mL
50 mM 0.0622 mL 0.3110 mL 0.6221 mL 1.5552 mL
60 mM 0.0518 mL 0.2592 mL 0.5184 mL 1.2960 mL
80 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.9720 mL
100 mM 0.0311 mL 0.1555 mL 0.3110 mL 0.7776 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Rosiptor
目录号:
HY-109011
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