1. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. PPAR Mitochondrial Metabolism
  3. (S)-Coriolic acid

(S)-Coriolic acid  (Synonyms: 13(S)-HODE)

目录号: HY-113884B 纯度: ≥99.0%
COA 产品使用指南

(S)-Coriolic acid (13(S)-HODE) ,亚油酸的15-脂氧合酶 (15-LOX) 代谢产物,作为内源性配体激活 PPARγ。(S)-Coriolic acid 是一种重要的细胞内信号剂,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 诱导线粒体功能障碍 (mitochondrial dysfunction) 和气道上皮损伤。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

(S)-Coriolic acid Chemical Structure

(S)-Coriolic acid Chemical Structure

CAS No. : 29623-28-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
100 μg (337.33 μM * 1 mL in Ethanol) ¥4000
In-stock
250 μg (337.33 μM * 2.5 mL in Ethanol) ¥8000
In-stock

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury[1][2][3].

体外研究
(In Vitro)

(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium[2].
(S)-Coriolic acid (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (6-8 weeks)[2]
Dosage: 0-0.6 mg per mouse
Administration: Intranasally once a day for 3 consecutive days
Result: BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.
分子量

296.44

Formula

C18H32O3

CAS 号
性状

液体

颜色

Colorless to light yellow

初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: ≥99.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
(S)-Coriolic acid
目录号:
HY-113884B
需求量: