2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. SAK3

SAK3 是一种有效的 T 型电压门控 Ca2+ 通道 (T-VGCC) 增强剂。SAK3 增强 Cav3.1 和 Cav3.3 T 型 Ca2+ 通道电流。急性 SAK3 给药可改善嗅球切除小鼠的记忆缺陷。SAK3 通过激活蛋白酶体活性抑制 APP-KI 小鼠中淀粉样蛋白 β 斑块形成。

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SAK3 Chemical Structure

SAK3 Chemical Structure

CAS No. : 1256269-87-0

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规格 价格 是否有货 数量
1 mg ￥1600
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Customer Review

SAK3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2].

体外研究
(In Vitro)

SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SAK3 相关抗体:

Cell Viability Assay[2]

Cell Line: Cav3.1 or Cav3.3-overexpressing neuro2A cells
Concentration: 0.1 nM
Incubation Time: 270 s
Result: Rapidly increased Ca2+ currents
体内研究
(In Vivo)

Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Animal Model:Cav3.1 knockout (KO) mice[1]
Dosage: 0.5 mg/kg
Administration: Administered p.o.
Result: Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
分子量

369.41

Formula

C20H23N3O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (277 KB) 元素分析报告 (223 KB)

产品使用指南 (1538 KB)
参考文献

SAK3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAK31256269-87-0SAK 3SAK-3Calcium ChannelCa2+ channelsCa channels含羞草氨酸Inhibitorinhibitorinhibit

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目录号：
HY-120597
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