2. Metabolic Enzyme/Protease Anti-infection
  3. Lipoxygenase Fungal
  4. Sclerotiorin

Sclerotiorin  (Synonyms: 核盘菌素)

目录号: HY-116866
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摩尔计算器

Sclerotiorin 是一种可逆且非竞争性的大豆脂氧化酶-1 (LOX-1) 抑制剂 (IC50: 4.2 μM)。Sclerotiorin 还具有清除自由基的抗氧化活性 (ED50: 0.12 μM) 和非酶脂质过氧化抑制活性。Sclerotiorin 具有抗真菌活性，还可以抑制血小板聚集。Sclerotiorin 可以从Penicillium permanentans 的发酵液中纯化出来。

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Sclerotiorin Chemical Structure

Sclerotiorin Chemical Structure

CAS No. : 549-23-5

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Sclerotiorin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans[1][2].

体外研究
(In Vitro)

Sclerotiorin (10 μM) 可在体外减缓 Aβ42 纤维形成 (使用 6E10 抗体检测)[2]。
Sclerotiorin 对革兰氏阳性菌具有窄谱抗菌活性，MIC 范围为128-1028 μg/mL[3]。
Sclerotiorin 在体外抑制胆固醇酯转移蛋白 (CETP) 活性 (IC50: 19.4 μM)[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sclerotiorin 相关抗体:
分子量

390.86

Formula

C21H23ClO5
CAS 号
中文名称

核盘菌素
结构分类
初始来源

Penicillium multicolor
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Sclerotiorin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sclerotiorin549-23-5核盘菌素LipoxygenaseFungalLOXantioxidantradicallipid peroxidationantifungalplatelet aggregationInhibitorinhibitorinhibit

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