Se-Methylselenocysteine hydrochloride  (Synonyms: L-硒甲基硒代半胱氨酸; Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride)

Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis^[1][2].

Se-Methylselenocysteine hydrochloride (100-400 μM；3 天) 诱导 SKOV-33 细胞凋亡^[1]。
Se-Methylselenocysteine hydrochloride (100-400 μM；3 天) 诱导 caspase-3 介导的细胞凋亡^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Se-Methylselenocysteine hydrochloride (0.2 mg/只小鼠；口服；每日一次，持续 14 天) 在携带人 FaDu 和 A253 头颈异种移植物的裸鼠中增强 CDDP 和环磷酰胺的抗肿瘤活性^[2]。
阿尔茨海默氏病 (AD) 小鼠在其饮用水中加入硒-甲基硒代半胱氨酸 (每天 0.75 mg/kg体重) 处理 10 个月。Se-Methylselenocysteine hydrochloride 减少氧化应激和神经炎症；Se-Methylselenocysteine hydrochloride 调节多种金属离子的分布和水平；Se-Methylselenocysteine hydrochloride 通过抑制其前体蛋白 APP 和 β-分泌酶 (BACE1) 的表达来减少淀粉样蛋白-β 肽 (Aβ) 的生成，并通过促进蛋白磷酸酶 2A (PP2A) 活性来减弱 tau 过度磷酸化和神经原纤维缠结 (NFT) 的形成，从而保护突触蛋白和神经元活动，最终改善 AD 模型小鼠的空间学习和记忆缺陷^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

218.54

C₄H₁₀ClNO₂Se

863394-07-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.  [Content Brief]

  [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.  [Content Brief]

  [3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.  [Content Brief]