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Secretin (swine)  (Synonyms: 促胰液素)

目录号: HY-109538
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Secretin (swine)，是一种神经内分泌激素，是第一个被识别的激素，主要由定位于十二指肠黏膜的 S 细胞分泌。Secretin 也是一个由 27 个氨基酸组成的多肽，作用于分泌素受体。Secretin 在所有成熟的肠内分泌细胞亚群中都有表达，并可由脂肪酸促进。Secretin 刺激胰腺水和碳酸氢盐的分泌。Secretin 在器官中发挥多种作用，可用于消化系统、中枢神经系统和能量代谢的研究。

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Secretin (swine) Chemical Structure

Secretin (swine) Chemical Structure

CAS No. : 17034-35-4

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Secretin (swine) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism[1][2].

体外研究
(In Vitro)

Secretin (swine) (10−7M, 10−6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling[2].
Secretin (10−7M, 10−6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines[2][3][4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Secretin (swine) 相关抗体:

Immunofluorescence[2]

Cell Line: large murine cholangiocyte lines
Concentration: 10−7M, 10−6 M
Incubation Time: 24 to 72 h and 7 days
Result: Increased the proliferation of cholangiocytes.

Cell Proliferation Assay[2]

Cell Line: human HIBEpiC and large murine cholangiocyte lines
Concentration: 10−7M, 10−6M
Incubation Time: 24 to 72 h and 7 days
Result: Increased the proliferation of non-transfected, vector-transfected and secretin shRNA large cholangiocytes and HiBEpiC compared to the cell lines treated with BSA (basal).
体内研究
(In Vivo)

Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sct＋/－mice[2]
Dosage: 2.5 nM/kg
Administration: 2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
Result: Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.
Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct＋/－mice.
Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue[2].
分子量

3055.41

Formula

C130H220N44O41
CAS 号
中文名称

促胰液素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Secretin (swine)17034-35-4促胰液素Othersneuroendocrine hormoneS cellspeptidesecretin receptorsenteroendocrine celldigestive systemcentral nervous systemenergy metabolismInhibitorinhibitorinhibit

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