2. Neuronal Signaling
  3. Tau Protein
  4. Semorinemab

Semorinemab  (Synonyms: RG 6100; RO7105705; MTAU-9937A)

目录号: HY-P99399 纯度: 99.90%
COA

摩尔计算器

Semorinemab (RG 6100) 是一种抗 Tau 人源化 IgG4 单克隆抗体，靶向 Tau 蛋白的 N 端部分(氨基酸残基 6-23)。Semorinemab 与人 Tau 蛋白结合的 Kd 值为 3.8 nM。Semorinemab 可用于阿尔茨海默病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Semorinemab Chemical Structure

Semorinemab Chemical Structure

CAS No. : 2159141-27-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Semorinemab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1].

体外研究
(In Vitro)

Semorinemab 与人 Tau 蛋白和重组食蟹猴 Tau 蛋白结合的 Kd 值分别为 3.8 和 11.2 nM[1]。
Semorinemab 阻止神经元摄取低聚 Tau[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Semorinemab 相关抗体:
体内研究
(In Vivo)

Semorinemab (3，10 和 30 mg/kg；腹腔注射，每周一次，持续 13 周) 减少 Tau 病状的转基因 (Tg) 小鼠模型中 Tau 的积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1]
Dosage: 3, 10 and 30 mg/kg
Administration: Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
Result: Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Semorinemab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Semorinemab2159141-27-0RG 6100 RO7105705 MTAU-9937ARG6100RG-6100RO7105705RO 7105705RO-7105705Tau ProteinantibodyAlzheimer's Diseasecynomolgus monkeyneuronmiceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Semorinemab
目录号：
HY-P99399
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z