2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway
  3. SHP2 ERK
  4. SHP2-IN-44

SHP2-IN-44 (Compound 26) 是一种变构的、具有口服活性的 SHP2 抑制剂，其 IC50 为 27 nM。SHP2-IN-44 还能抑制 ERK 磷酸化 (IC50 为 299 nM)，且不具有脱靶 hERG 活性。SHP2-IN-44 具有广谱抗癌活性，如治疗幼年型粒单核细胞白血病、神经母细胞瘤和乳腺癌。SHP2-IN-44 可用于努南综合征、LEOPARD 综合征和癌症研究。

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SHP2-IN-44

SHP2-IN-44 Chemical Structure

CAS No. : 2818955-47-2

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SHP2-IN-44 相关抗体

Top Publications Citing Use of Products

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC50 of 27  nM. SHP2-IN-44 also inhibits ERK phosphorylation (IC50 of 299  nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer. SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research[1].

分子量

471.98

Formula

C22H23ClFN7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHP2-IN-44 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP2-IN-442818955-47-2SHP2ERKSrc homology phosphatase 2PTPN11Extracellular signal regulated kinasesERK phosphorylationAnticancerNoonan syndromeLEOPARD syndromeJuvenile myelomonocytic leukemiaNeuroblastomaBreast cancerInhibitorinhibitorinhibit

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