2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Sigma Receptor
  4. SKF 83959

SKF83959 是一种有效的选择性多巴胺 D1-like 受体部分激动剂。SKF83959 Ki 对大鼠 D1，D5，D2和D3 的值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是一种有效的 sigma (σ)-1 受体变构调节剂。SKF83959 属于 benzazepine 家族，对认知功能障碍有改善作用。SKF83959 可用于研究阿尔茨海默病和抑郁症。

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SKF 83959 Chemical Structure

SKF 83959 Chemical Structure

CAS No. : 80751-85-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2750
In-stock
5 mg ￥2500
In-stock
10 mg ￥4000
In-stock
25 mg ￥8000
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of SKF 83959:

SKF 83959 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression[1][2][3][4].

IC50 & Target[3][4]

D1 Receptor

1.18 nM (Ki)

Sigma 1 Receptor

 

D5 Receptor

7.56 nM (Ki)

D2 Receptor

920 nM (Ki)

D3 Receptor

399 nM (Ki)

体外研究
(In Vitro)

SKF83959 (10~250 μM) stimulates PIP2 hydrolysis in membranes. SKF83959 (0.1~10 μM; PC12 cell) changes the EC50 value of SKF81297 from 0.5 nM in control tissue to 31.6 nM, 251.2 nM and 631.0 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SKF 83959 相关抗体:
体内研究
(In Vivo)

SKF83959 (0.5 and 1 mg/kg; i.p.; 1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test[1].
SKF83959 (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade[1].
SKF83959 has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR male mice (8 weeks)[1]
Dosage: 0.5 and 1 mg/kg
Administration: I.p.; 1 hour
Result: Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
Animal Model: Male ICR male mice (8 weeks)[1]
Dosage: 1 mg/kg
Administration: I.p.; 30 minutes
Result: The memory enhancing effects were prevented by BDNF system blockade.
分子量

317.81

Formula

C18H20ClNO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (314.65 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1465 mL 15.7327 mL 31.4653 mL
5 mM 0.6293 mL 3.1465 mL 6.2931 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SKF 83959 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1465 mL 15.7327 mL 31.4653 mL 78.6634 mL
5 mM 0.6293 mL 3.1465 mL 6.2931 mL 15.7327 mL
10 mM 0.3147 mL 1.5733 mL 3.1465 mL 7.8663 mL
15 mM 0.2098 mL 1.0488 mL 2.0977 mL 5.2442 mL
20 mM 0.1573 mL 0.7866 mL 1.5733 mL 3.9332 mL
25 mM 0.1259 mL 0.6293 mL 1.2586 mL 3.1465 mL
30 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6221 mL
40 mM 0.0787 mL 0.3933 mL 0.7866 mL 1.9666 mL
50 mM 0.0629 mL 0.3147 mL 0.6293 mL 1.5733 mL
60 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3111 mL
80 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.9833 mL
100 mM 0.0315 mL 0.1573 mL 0.3147 mL 0.7866 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 8395980751-85-5SKF83959SKF-83959Dopamine ReceptorSigma ReceptorPC12PIP2hydrolysisdopaminebenzazepinecognitivedysfunctionAlzheimerInhibitorinhibitorinhibit

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目录号：
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