2. Protein Tyrosine Kinase/RTK
  3. Src
  4. SRC-3-IN-1

SRC-3- in -1 (compound SI-10) 是一种类固醇受体共激活因子 3 (SRC-3) 抑制剂(IC50=3.3 μM)。SRC-3-IN-1 具有良好的水溶性、口服生物利用度和选择性。SRC-3-IN-1 可用于前列腺癌研究。

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SRC-3-IN-1 Chemical Structure

SRC-3-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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100 mg   询价  
250 mg   询价  

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Customer Review

SRC-3-IN-1 相关抗体

Top Publications Citing Use of Products

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SRC-3-IN-1(compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor(IC50=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research[1].

体外研究
(In Vitro)

SRC-3-IN-1(不同浓度， 72 h) 对多种癌细胞系有高效力[1]。
SRC-3-IN-1 对非靶标具有高选择性与其个位数纳米分子效力相比[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SRC-3-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: Panc-1, HPAC, Mpanc-96, MDA-MB-468, MCF-7, BT-474 and LNCaP cell lines
Concentration:
Incubation Time: 72 h
Result: Exhibited very potent cytotoxicity against these cell lines, with IC50 values ranging from 1 to 32 nM
体内研究
(In Vivo)

SRC-3-IN-1(50， 100 mg/kg， po； 连续 4 周每天服用) 不会导致小鼠体重下降[1]。
SRC-3-IN-1(10mg /kg， ip； 每天一次持续 4 周) 通过抑制肿瘤血管生成而延长小鼠存活时间[1]。
SRC-3-IN-1(10mg /kg/day， ip； 每天一次持续4周) 使肿瘤面积与股骨面积之比降低 50% 以上[1]。

Pharmacokinetic Analysis in CD-1 Mice[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0_t (ng•h/mL) Cl (L•h/kg) F (%)
i.v. 1 3.25 0.033 552 87.6 176 /
p.o. 10 9.09 0.25 89 477 / 54.4

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: xenograft prostate cancer mouse model[1]
Dosage: 10 mg/kg
Administration: i.p.
Result: Resulted in a substantial inhibition of tumor growth after only 1 week and exhibited a remarkable reduction in tumor growth by more than 65% compared to the vehicle after 4 weeks.
分子量

302.28

Formula

C14H12F2N6
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SRC-3-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRC-3-IN-1SrcSRC-3 inhibitorPanc-1HPACMpanc-96MDA-MB-468MCF-7BT-474 and LNCaP cell linesprostatic cancerInhibitorinhibitorinhibit

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目录号：
HY-163468
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