1. Anti-infection Cell Cycle/DNA Damage Immunology/Inflammation Autophagy Apoptosis
  2. Reverse Transcriptase HIV Nucleoside Antimetabolite/Analog NOD-like Receptor (NLR) Autophagy Apoptosis
  3. Stavudine sodium

Stavudine sodium  (Synonyms: 司他夫定钠; d4T sodium)

目录号: HY-B0116A
产品使用指南

Stavudine (d4T) sodium 是一种口服活性核苷逆转录酶抑制剂 ((NRTI))。Stavudine sodium 具有抗 HIV-1HIV-2 的活性。Stavudine sodium 还抑制线粒体 DNA (mtDNA) 的复制。Stavudine sodium 降低 NLRP3 炎症小体激活,调节淀粉样 β 自噬。Stavudine sodium 诱导细胞凋亡。

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Stavudine sodium Chemical Structure

Stavudine sodium Chemical Structure

CAS No. : 134624-73-0

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Stavudine sodium 的其他形式现货产品:

Other Forms of Stavudine sodium:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis[1][2][3][4].

IC50 & Target

HIV-1

 

HIV-2

 

NLRP3

 

体外研究
(In Vitro)

Stavudine (d4T) sodium (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages[3].
Stavudine (d4T) sodium (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages[3].
Stavudine (d4T) sodium (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male RjOrl Swiss mice weighing 0.028-0.03 kg[1]
Dosage: 500 mg/kg
Administration: Daily liquid; 2 weeks
Result: Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.
Significantly elevated plasma ALT and LDH levels.
Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.
Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.
Clinical Trial
分子量

246.20

Formula

C10H11N2NaO4

CAS 号
中文名称

司他夫定钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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