2. Immunology/Inflammation Apoptosis
  3. STING Cyclic GMP-AMP Synthase IFNAR TNF Receptor Interleukin Related
  4. STING agonist-45

STING agonist-45 是一种选择性的 STING 激动剂 (EC50 = 0.28 μM)。STING agonist-45 通过 cGAS-STING 通路激活先天免疫反应，上调 p-TBK1 和 IRF3 等关键标志物。STING agonist-45 在人外周血单核细胞 (PBMC) 中表现出强大的 STING 激活作用，诱导 I 型干扰素 (如IFN-β) 以及下游细胞因子 (如TNF-α和IL-6) 产生。STING agonist-45 在小鼠模型中增强抗肿瘤免疫力，抑制肿瘤生长，增加 CD8+ T 细胞浸润。STING agonist-45 可用于 STING 相关疾病研究。

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STING agonist-45

STING agonist-45 Chemical Structure

CAS No. : 2361424-97-5

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STING agonist-45 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STING agonist-45 is a selective STING agonist (EC50 = 0.28 μM). STING agonist-45 activates the innate immune response through the cGAS-STING pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6). STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8+ T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases[1][2].

体外研究
(In Vitro)

STING agonist-45 (Compound 12L) (24 小时) 在 RAW 264.7 细胞中诱导报告信号，EC50 值为 5.22 µM[1]。
STING agonist-45 (24 小时) 对 THP1 细胞表现出明显的细胞毒性[1]。
STING agonist-45 (24 小时) 可与各种 hSTING 等位基因 (IC50 = 8.97 µM) 和 mSTING (IC50 = 4.35 µM) 的羧基末端结构域 (CTD) 结合[1]。
STING agonist-45 (Example 1) (24 小时) 刺激 THP1 细胞产生 CXCL10 (IP10) 细胞因子， EC50 值为 1.6 µM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-45 相关抗体:
体内研究
(In Vivo)

STING agonist-45 (Compound 12L) (3-30 mg/kg，静脉注射，每日一次，4 天) 在 C57BL/6 小鼠模型中诱导 IFN-β 蛋白[1]。
STING agonist-45 (10 mg/kg，静脉注射，每日一次，7 天) 在 B16.F10 荷瘤 C57BL/6 小鼠模型中缩小肿瘤体积，延长生存时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (6-8 weeks old) model[1]
Dosage: 3, 10, 30 mg/kg
Administration: i.v., once a day, 4 days
Result: Dose-dependent induced IFN-β protein.
Animal Model: B16.F10 tumor-bearing (105) C57BL/6 mice (6-8 weeks old) model[1]
Dosage: 10 mg/kg
Administration: i.v., once a day, 7 days
Result: Reduced tumor volume, prolonged the survival time.
分子量

426.47

Formula

C21H26N6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STING agonist-45 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-452361424-97-5STING agonist45STING agonist 45STINGCyclic GMP-AMP SynthaseIFNARTNF ReceptorInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYScGASInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRILAgonistB16.F10 cellsRAW 264.7 cellsTHP1 cellsMelanomaInhibitorinhibitorinhibit

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