2. Cytoskeleton MAPK/ERK Pathway GPCR/G Protein
  3. Dynamin Ras
  4. Sulfonadyn-47

Sulfonadyn-47 是一种 GTP 竞争性动力蛋白I (dynI) 抑制剂，靶向作用于动力蛋白I (dynI) GTPase 结构域的活性位点，其抑制活性表现为：针对 dynI 的 IC50 值为 3.5 μM，在网格蛋白介导的内吞作用 (CME) 实验中为 27.3 μM，在突触小泡内吞作用 (SVE) 实验中为 12.3 μM。Sulfonadyn-47 能提高癫痫发作阈值，Sulfonadyn-47 可用于癫痫相关研究。

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Sulfonadyn-47 Chemical Structure

Sulfonadyn-47 Chemical Structure

CAS No. : 3064686-59-2

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Sulfonadyn-47 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure[1].

体外研究
(In Vitro)

Sulfonadyn-47 对动力蛋白 I 显示出抑制活性，对动力蛋白 I 的 IC50 值为 3.5 μM，在网格蛋白介导的内吞作用 (CME) 实验中的 IC50 为 27.3 μM，在突触小泡内吞作用 (SVE) 实验中的 IC50 为12.3 μM[1]。

Sulfonadyn-47 (80 μM) 对突触体中的谷氨酸释放无显著影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfonadyn-47 相关抗体:
体内研究
(In Vivo)

Sulfonadyn-47 (10-60 mg/kg, i.p.) 可提高丙戊酸盐诱导的 6 Hz 急性癫痫小鼠模型的癫痫发作阈值[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Valproate induced 6 Hz acute seizures mouse model
Dosage: 10, 30, 60 mg/kg
Administration: i.p. 30 min before stimulation
Result: Increased seizure threshold at doses of 30 and 60 mg/kg dose-dependently, with the threshold for the 60 mg/kg dose being equivalent to that to induce seizures in 50% of mice given 400 mg/kg of valproate.
分子量

459.40

Formula

C22H23BrN2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sulfonadyn-47 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfonadyn-473064686-59-2Sulfonadyn47Sulfonadyn 47DynaminRasU2OSGTPaseseizuredynaminInhibitorinhibitorinhibit

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