1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Sulprostone

Sulprostone  (Synonyms: 硫前列酮; SHB 286; CP-34089; ZK-57671)

目录号: HY-19360 纯度: ≥98.0%
COA 产品使用指南

Sulprostone (SHB 286) 是一种有效的,选择性的 EP3 受体激动剂。Sulprostone (SHB 286) 是一种前列腺素 E2 (PGE2) 类似物,具有抗溃疡和非甾体类抗流产作用。Sulprostone 有潜力用于终止妊娠和分娩时的出血。

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Sulprostone Chemical Structure

Sulprostone Chemical Structure

CAS No. : 60325-46-4

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1mg (10.74 mM * 200 μL in Methyl acetate) ¥3000
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery[1][2][3].

IC50 & Target[1][2]

EP3

 

体外研究
(In Vitro)

Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male cynomolgus monkey[3]
Dosage: 0.5 mg/kg (Pharmacokinetic Analysis)
Administration: IV
Result: Had a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL.
Clinical Trial
分子量

465.56

Formula

C23H31NO7S

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

硫前列酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: ≥99.0%

参考文献

Sulprostone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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