1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Sulprostone

Sulprostone (Synonyms: SHB 286; CP-34089; ZK-57671)

目录号: HY-19360
产品使用指南

Sulprostone (SHB 286) 是一种前列腺素 E2 (PGE2) 类似物,是一种有效且选择性的 EP3 受体激动剂。Sulprostone 是具有抗溃疡和非甾体类抗流产作用,有潜力用于终止妊娠和分娩时的出血。

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Sulprostone Chemical Structure

Sulprostone Chemical Structure

CAS No. : 60325-46-4

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Description

Sulprostone (SHB 286), a prostaglandin E2 (PGE2) analogue, is a potent and selective EP3 receptor agonist. Sulprostone has potential antiulcer and nonsteroidal abortifacient effects used for the research of pregnancy termination and hemorrhages during delivery[1][2][3].

IC50 & Target[1][2]

EP3 Receptor

 

In Vitro

Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs[2].

In Vivo

Sulprostone (0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL[3].

Animal Model: Male cynomolgus monkey[3]
Dosage: 0.5 mg/kg (Pharmacokinetic Analysis)
Administration: IV
Result: Had a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL.
Molecular Weight

465.56

Formula

C₂₃H₃₁NO₇S

CAS No.

60325-46-4

中文名称

硫前列酮

SMILES

O=C(NS(=O)(C)=O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)CC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
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Keywords:

SulprostoneSHB 286CP-34089ZK-57671SHB286SHB-286CP34089CP 34089ZK57671ZK 57671Prostaglandin ReceptorprostaglandinE2PGE2antiulcernonsteroidalabortifacientpregnancyterminationhemorrhagesInhibitorinhibitorinhibit

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产品名称:
Sulprostone
目录号:
HY-19360
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