2. Apoptosis
  3. TNF Receptor
  4. Tabalumab

Tabalumab  (Synonyms: LY2127399)

目录号: HY-P99220 纯度: 98.11%
COA

摩尔计算器

Tabalumab (LY2127399) 是一种人源的抗 BAFF (B细胞激活因子) 单克隆抗体 (IgG4 型)，对膜结合和可溶性 BAFF 具有中和活性。Tabalumab 可用于自身免疫性疾病，如类风湿性关节炎、肾衰竭和系统性红斑狼疮的研究。

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Tabalumab Chemical Structure

Tabalumab Chemical Structure

CAS No. : 1143503-67-6

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1 mg ￥1200
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5 mg ￥3600
In-stock
10 mg ￥6100
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Tabalumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus[1].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

BAFF[1].
体外研究
(In Vitro)

Tabalumab (1-100 ng/mL; 44 h) neutralizes soluble and membrane-bound BaFF both in T1165.17 cells and (1 µg/mL; 3 days) CD19+ B-cells[1].
Tabalumab (50 µg/mL; 15 min) inhibits BaFF binding to BR3, TacI, and BcMa in HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tabalumab 相关抗体:

Cell Viability Assay[1]

Cell Line: T1165.17 cells
Concentration: 1-100 ng/mL
Incubation Time: 44 h
Result: Neutralizeed tabalumab neutralization of soluble human, cynomolgus monkey, or rabbit BAFF with IC50 values of 104, 143, and 176 pM in T1165.17 cells, respectively.

Cell Viability Assay[1]

Cell Line: CD19+ B-cells
Concentration: 1 µg/mL
Incubation Time: 3 days
Result: Demonstrated the ability to neutralize the membrane-bound form of BAFF compared with the soluble form of BAFF.

Cell Viability Assay[1]

Cell Line: HEK293 cells (transfected with either BR3, TACI, or BCMA)
Concentration: 50 µg/mL
Incubation Time: 15 min (pre-treat)
Result: Prevented the binding of BAFF to BR3, TACI, or BCMA on the cell surface.
体内研究
(In Vivo)

Tabalumab (500 µg/rat; s.c.; single) leads to decreased B-cells and a reduction in non-canonical nF-κB signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human BAFF Tg mice[1].
Dosage: 500 µg/rat
Administration: Subcutaneous injection, single.
Result: Significantly decreased the splenic B-cell count between day 4 and 8.
Decreased levels of p52, which returned to near the BAFF Tg level at Day 23.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tabalumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tabalumab1143503-67-6LY2127399LY 2127399LY-2127399TNF ReceptorTumor Necrosis Factor ReceptorTNFRrheumatoid arthritissystemic lupus erythematosusIgG4autoimmune diseasesT1165.17CD19+ B-cellsHEK293Inhibitorinhibitorinhibit

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