2. Others Vitamin D Related/Nuclear Receptor Autophagy Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Autophagy HSP Isotope-Labeled Compounds Estrogen Receptor/ERR Apoptosis
  4. Tamoxifen-13C6

Tamoxifen-13C6  (Synonyms: ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6)

目录号: HY-W778408
产品使用指南 技术支持

Tamoxifen-13C6 (ICI 47699-13C6) 是 13C 标记的 Tamoxifen (HY-13757A)。Tamoxifen (ICI 47699) 是一种口服有效的，选择性雌激素受体 (estrogen receptor) 调节剂 (SERM)，可阻断乳腺细胞中的雌激素作用，并可激活其他细胞，如骨骼，肝脏和子宫细胞中的雌激素活性。Tamoxifen 是一种有效的 Hsp90 激活剂，可增强 Hsp90 分子伴侣 ATPase 的活性。Tamoxifen 还可以有效抑制传染性 EBOV Zaire 和 Marburg (MARV)，IC50 分别为 0.1 μM 和 1.8 μM。Tamoxifen 可以激活自噬 (autophagy)，诱导凋亡 (apoptosis)。Tamoxifen 还可以诱导 CreER 转基因小鼠的基因敲除。

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Tamoxifen-<sup>13</sup>C<sub>6</sub> Chemical Structure

Tamoxifen-13C6 Chemical Structure

CAS No. : 1346606-38-9

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Other Forms of Tamoxifen-13C6:

Tamoxifen-13C6 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

生物活性

Tamoxifen-13C6 (ICI 47699-13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[5]. Tamoxifen activates autophagy and induces apoptosis[4]. Tamoxifen also can induce gene knockout of CreER transgenic mouse[6].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tamoxifen-13C6 相关抗体:
分子量

377.47

Formula

C2013C6H29NO
CAS 号
非标记 CAS
中文名称

他莫昔芬-13C6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Tamoxifen-13C6 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tamoxifen-13C61346606-38-9ICI 47699-13C6(Z)-Tamoxifen-13C6 trans-Tamoxifen-13C6他莫昔芬-13C6AutophagyHSPIsotope-Labeled CompoundsEstrogen Receptor/ERRApoptosisHeat shock proteinsInhibitorinhibitorinhibit

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