1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Taprostene

Taprostene  (Synonyms: CG-4203)

目录号: HY-114671
产品使用指南

Taprostene (CG-4203) 是一种合成的、化学稳定的前列环素 (PGI2) 类似物。Taprostene 在猫急性心肌缺血再灌注后表现出内皮和心肌保护作用。Taprostene 增强细胞保护作用,同时最大限度地减少不必要的血液动力学影响。

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Taprostene Chemical Structure

Taprostene Chemical Structure

CAS No. : 108945-35-3

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规格 价格 是否有货 数量
1 mg ¥3672
3 - 4 周
5 mg   询价  
10 mg   询价  

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Taprostene (CG-4203) is a synthetic, chemically stable analogue of Prostacyclin (PGI2). Taprostene exhibits endothelium and myocardial protecting actions after acute myocardial ischemia and reperfusion in cats. Taprostene enhances cytoprotective actions, while minimizing unwanted hemodynamic effects[1].

IC50 & Target

Prostaglandin Receptor[1]

体内研究
(In Vivo)

Taprostene (100 ng/kg/min) is infused intravenously starting 30 minutes postocclusion of the left anterior descending coronary artery followed by reperfusion 1 hour later in a 6-hour model of myocardial ischemia (MI) with reperfusion in anesthetized cats. Taprostene infusion results in significantly lower plasma creatine phosphokinase activities for the MI + Taprostene group compared with the MI + vehicle group.Taprostene has a profile of activity including prevention of aggregation in cat platelets15 at concentrations that are much lower than that required to produce significant vasodilator activity in rabbit aortic rings. In addition to antiaggregatory and cytoprotective effects in circulatory shock, Taprostene exerts beneficial effects in acute inflammatory states and in rat models of myocardial hypoxia and permanent ischemia.A variety of infusion rates of Taprostene from 50 to 200 ng/kg/min were initially used to obtain an infusion rate that produced minimal hemodynamic (i.e., vasodilator) effects but still exerted cardioprotective effects. Taprostene treatment inhibits neutrophils adhering to the myocardial endothelium in both jeopardized and necrotic myocardial tissue after ischemia and reperfusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male cats (2.5-3.5 kg)[1]
Dosage: 100 ng/kg
Administration: Infused intravenously at a rate of 100 ng/kg/min until the end of the experiment (i.e., for 5.5 hours).
Result: In six cat aortic rings, 1-100 ng/mL failed to exert any vasorelaxant effect. Relaxed the vascular rings 34% at 300 ng/mL. The EC50 was 520 ng/mL, a value 26 times that of its antiplatelet aggregatory effect in cat platelet-rich plasma.
分子量

398.49

Formula

C24H30O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Taprostene 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-114671
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