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TCS 2510 是一种选择性 EP4 激动剂。TCS 2510 可用于代谢疾病的研究。

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TCS 2510 Chemical Structure

TCS 2510 Chemical Structure

CAS No. : 346673-06-1

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500μg(13.04 mM * 100 μL in ethanol) ¥5500
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases[1].

IC50 & Target

EP4[1]

体外研究
(In Vitro)

TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration[1].
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 0.1~10 mg/kg
Administration: P.o.
Result: Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
Animal Model: Mice[1]
Dosage: 10 mg/kg
Administration: P.o.
Result: Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
Animal Model: Mice[1]
Dosage: 1~10 mg/kg
Administration: P.o.
Result: Afforded a significant elevation in plasma glucagon like peptide 2 levels.
分子量

383.49

Formula

C21H29N5O2

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: ≥98.0%

参考文献

TCS 2510 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TCS 2510
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HY-108557
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