2. Immunology/Inflammation
  3. CD3
  4. Teclistamab

Teclistamab 

目录号: HY-P99392 纯度: 99.87%
COA

摩尔计算器

Teclistamab 是一种人源的 BCMA 和 CD3 双特异性抗体，可识别靶细胞上的 BCMA 和 T 细胞上的 CD3，诱导 T 细胞介导的细胞毒性，导致 T 细胞的活化和随后的靶细胞裂解。Teclistamab 可用于多发性骨髓瘤等相关疾病研究。

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Teclistamab Chemical Structure

Teclistamab Chemical Structure

CAS No. : 2119595-80-9

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规格 价格 是否有货 数量
1 mg ￥8500
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Customer Review

Teclistamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM)[1].

体外研究
(In Vitro)

Teclistamab (0.01-1000 nM, 48 h) 可以诱导 T 细胞介导的细胞毒性，在 H929 细胞中的 EC50 值为 0.15 nM，在MM.1R 细胞系中为 0.06 nM，在 RPMI 8226 细胞系中为 0.45 nM[1]。
Teclistamab (0.01-1000 nM, 48 h) 能以剂量依赖方式结合 CD138 +人 BM 单核细胞，并诱导人 BM 单核细胞的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Teclistamab 相关抗体:
体内研究
(In Vivo)

Teclistamab (i.v., 0.1-1 μg, once every 2 days) 在雌性 NSG（NOD/SCID/γc-/）小鼠 H929 细胞模型中具有大剂量的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG mice infected with H929 cell lines[1]
Dosage: 0.1 µg (0.005 mg/kg), 0.5 µg (0.025 mg/kg), or 1 µg (0.05 mg/kg)
Administration: i.v., on days 0, 3, 5, 7, and 10
Result: Completely inhibited tumor growth at doses of 0.5 and 1 μg, while no inhibition of tumor growth was observed at a dose of 0.1 μg.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.87%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Teclistamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teclistamab2119595-80-9CD3Cluster of differentiation 3BCMAT cellsmultiple myelomaInhibitorinhibitorinhibit

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