1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide-O-C8-COOH

Thalidomide-O-C8-COOH 

目录号: HY-130952 纯度: 95.30%
产品使用指南

Thalidomide-O-C8-COOH 是一种基于 Thalidomide 的,可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-O-C8-COOH 可通过 linker 与靶蛋白配体连接,形成 PROTAC 分子。

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Thalidomide-O-C8-COOH Chemical Structure

Thalidomide-O-C8-COOH Chemical Structure

CAS No. : 2225148-51-4

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Description

Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

430.45

Formula

C₂₂H₂₆N₂O₇

CAS No.

2225148-51-4

SMILES

O=C(O)CCCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide-O-C8-COOHLigand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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产品名称:
Thalidomide-O-C8-COOH
目录号:
HY-130952
需求量: