1. PROTAC
  2. PROTAC Linker
  3. THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH 

目录号: HY-130820
产品使用指南

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH 是基于 PEG 结构的 PROTAC linker, 可以用来制备 PROTAC K-Ras Degrader-1 (HY-129523)。

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THP-PEG4-Pyrrolidine(N-Boc)-CH2OH Chemical Structure

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH Chemical Structure

CAS No. : 2378261-80-2

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Description

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

IC50 & Target

PEGs

 

In Vitro

PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

477.59

Formula

C₂₃H₄₃NO₉

CAS No.

2378261-80-2

SMILES

O=C(N1[C@H](CO)C[C@@H](OCCOCCOCCOCCOC2CCCCO2)C1)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

THP-PEG4-Pyrrolidine(N-Boc)-CH2OHPROTAC LinkercancerlinkerprotacdegraderkrasInhibitorinhibitorinhibit

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产品名称:
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
目录号:
HY-130820
需求量: