2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. THPN

THPN 是一种有效的 Nur77 激动剂。THPN 特异性结合 Nur77 (TR3) 的 LBD，而与维甲酸受体 α 和 PPARγ 结合的 Kd 为 270 nM。THPN 导致 Nur77 向线粒体转位，诱导黑色素瘤自噬细胞死亡。

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THPN Chemical Structure

THPN Chemical Structure

CAS No. : 100079-26-3

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规格 价格 是否有货
5 mg ￥2592
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THPN 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

IC50 & Target

Nur77/NR4A1

 

分子量

266.33

Formula

C15H22O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

THPN 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THPN100079-26-3Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like Receptormelanoma cellNur77TR3Inhibitorinhibitorinhibit

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