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  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 核受体化合物库
核受体化合物库 - Nuclear Receptor Compound Library

Cat. No.: HY-L126

核受体,是在细胞中发现的一类蛋白质,负责感知雄激素、甲状腺激素和某些其他分子。它是一种参与人体生理病理等多方面的配体激活转录因子,调节多种重要基因的表达。

核受体已成为新药开发策略中的主要靶点之一,为研究多种人类疾病提供了一种独特的受体,如乳腺癌、皮肤病和糖尿病等。13%的美国食品和药物管理局(FDA)批准的药物靶向核受体。

MCE可以提供665种核受体抑制剂和激动剂,所有化合物均明确报道对核受体有抑制或激活作用。MCE核受体库是癌症、皮肤病和糖尿病等相关药物研究的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 核受体化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,658 个产品以 10 mM 浓度提供,7 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•    A unique collection of 665 nuclear receptor inhibitors and activators for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool for studying the relationship between diseases and nuclear receptor.

•   Target diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

产品详情

Product Details

Formulation:

A collection of 665 nuclear receptor related compounds supplied as pre-dissolved Solutions or Solid
Solution: 658 compounds supplied in 10 mM solution, 7 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

PPAR (115)

FXR (28)

LXR (27)

ROR (27)

COX (7)

Akt (5)

Wnt (5)

HSP (4)

HIV (3)

IKK (3)

ERK (2)

GLUT (2)

HBV (2)

HSV (2)

PKC (2)

AMPK (1)

AP-1 (1)

CDK (1)

FGFR (1)

FLAP (1)

FOXO (1)

HCV (1)

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  •  特定化合物
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  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    Inquiry Information

    产品名称:
    Nuclear Receptor Compound Library
    目录号:
    HY-L126
    需求量: