2. Immunology/Inflammation
  3. CD3
  4. Tidutamab

Tidutamab  (Synonyms: XmAb-18087)

目录号: HY-P99562

摩尔计算器

Tidutamab (XmAb-18087) 是一种人源化和亲和优化的双特异性抗体 (bsAb)，靶向 SSTR2 结合域和 T 细胞结合域 (CD3)。Tidutamab 具有完整的 Fc 结构域以维持较长的血清半衰期。Tidutamab 通过刺激重定向 T 细胞介导的细胞毒性 (RTcC) 消除 SSTR+ 肿瘤细胞。

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Tidutamab Chemical Structure

Tidutamab Chemical Structure

CAS No. : 2148354-90-7

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Tidutamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC)[1].

体外研究
(In Vitro)

Tidutamab (XmAb-18087; 0-100000 ng/mL)与人 SSTR2+ CHO 细胞结合，ED50 值为 2.2 μg/mL，并介导 T 细胞杀伤 SSTR2+ 靶细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tidutamab 相关抗体:
体内研究
(In Vivo)

Tidutamab (XmAb-18087; 3 mg/kg; i.p.; 单次注射) 在 NSG 小鼠中刺激人 T 细胞杀伤 SSTR2+ A549 肺癌肿瘤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; single dose
Result: lnduced anti-tumor activity in human PBMC-engrafted NSG mice.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tidutamab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tidutamab2148354-90-7XmAb-18087XmAb18087XmAb 18087CD3Cluster of differentiation 3T-cellFc domainhalf-lifeserumSSTR+ tumorRTcCInhibitorinhibitorinhibit

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