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  3. Tigecycline hydrate

Tigecycline hydrate  (Synonyms: GAR-936 hydrate)

目录号: HY-B0117D
产品使用指南

Tigecycline (GAR-936) hydrate 是一种广谱的甘氨酰环素抗生素。Tigecycline hydrate 对 E. coli (MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/mL。对 Acinetobacter baumannii (A. baumannii) 的 MIC50 和 MIC90 分别为 1 和 2 mg/L。

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Tigecycline hydrate Chemical Structure

Tigecycline hydrate Chemical Structure

CAS No. : 1229002-07-6

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Tigecycline hydrate 的其他形式现货产品:

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Top Publications Citing Use of Products

    Tigecycline hydrate purchased from MCE. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Tigecycline against 43 M. fortuitum isolates (incubate for 24 h). The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tigecycline (GAR-936) hydrate is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline hydrate for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].

    体外研究
    (In Vitro)

    替加环素水合物(0.63-30 µM,预孵育 4 d,处理 72 h)抑制 AML2 细胞和 HL-60 细胞增殖,IC50 分别为 4.72 和 3.06 μM(新鲜制备)。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Human leukemic OCI-AML2, HL-60 (ATCC) and TEX cell lines
    Concentration: 0.63-30 µM
    Incubation Time: Preincubated for 4 days, treated for 72 hours
    Result: Inhibited AML2 cells and HL-60 cells with IC50s of 4.72 and 3.06 μM (freshly prepared).
    体内研究
    (In Vivo)

    替加环素水合物(50 mg/kg;腹腔注射;每天两次;持续 11 天)可减少 NOD/SCID 小鼠的肿瘤体积和重量[1]
    替加环素水合物(50 mg/kg;腹腔注射)在小鼠体内的血药峰浓度 (Cmax)、终末半衰期 (t1/2)、血药浓度-时间曲线下面积 (AUC)、清除率 (CL) 和分布体积 (Vz) 分别为 22.8μg/mL, 108.9 min, 1912.2min*μg/mL, 26.1 mL/min/kg, 4109.4 mL/kg[1]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NOD/SCID mice with OCI-AML2 acute myeloid leukemia (AML) xenograft model[1]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection; twice a day; for 11 days
    Result: Reduced tumor volume and weight.
    Animal Model: NOD/SCID mice[1]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection; 360 minutes
    Result: The peak plasma concentration (Cmax), the terminal half-life (t1/2), area under the plasma concentration-time curve (AUC), clearance (CL) and volume of distribution (Vz) are 22.8 μg/mL, 108.9 min, 1912.2 min*μg/mL, 26.1 mL/min/kg, 4109.4 mL/kg, respectively.
    Clinical Trial
    Formula

    C29H39N5O8.xH2O

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献

    Tigecycline hydrate 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    目录号:
    HY-B0117D
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