1. Anti-infection
  2. SARS-CoV
  3. Tixagevimab

Tixagevimab  (Synonyms: 替沙格韦单抗; AZD8895)

目录号: HY-P99556 纯度: ≥99.0%
COA 技术支持

Tixagevimab (AZD8895) 是一种人源单克隆抗体, 可以靶向SARS-CoV-2 受体结合结构域(RBD)。通过与 RBD 和 S 糖蛋白外域结合,并阻断 S 糖蛋白介导的与受体的结合而表现出对 SARS-CoV-2 的中和活性。

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CAS No. : 2420564-02-7

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规格 价格 是否有货 数量
1 mg ¥3000
In-stock
5 mg 现货 询价
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tixagevimab (AZD8895) is a human monoclonal antibody that targets the SARS-CoV-2 receptor binding domain (RBD). It exhibits neutralizing activity against SARS-CoV-2 by binding to the RBD and the S-glycoprotein ectodomain and blocking S-glycoprotein-mediated binding to the receptor[1].

同型

Human IgG4 kappa

推荐同型对照抗体
反应种属

Virus

IC50 & Target

Severe acute respiratory syndrome coronavirus 2

体内研究
(In Vivo)

Tixagevimab 可以与 Cilgavimab 组合,形成 AZD7442,AZD7442(2,4 或 16 mg/kg,静脉注射)在感染 G61 菌株的仓鼠以及在感染了 Omicron 变种的仓鼠中,可以导致肺部感染滴度和病毒 RNA 水平呈剂量依赖性下降,且与 2 mg/kg 剂量的动物相比,16 mg/kg 剂量的感染滴度显著降低[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

146.48 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

替沙格韦单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, His, HY-P74447) can bind Tixagevimab. The EC50 for this effect is 146.4 ng/mL.
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tixagevimab
目录号:
HY-P99556
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