1. Apoptosis
  2. Apoptosis
  3. TrxR inhibitor D9

TrxR inhibitor D9 

目录号: HY-136279
产品使用指南

TrxR inhibitor D9 是一种有效和选择性的硫氧还蛋白还原酶 (TrxR) 的抑制剂,EC50 值为 2.8 nM。TrxR inhibitor D9 具有在体外和体内抑制肿瘤增殖的能力。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

TrxR inhibitor D9 Chemical Structure

TrxR inhibitor D9 Chemical Structure

CAS No. : 1527513-89-8

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo[1][2].

IC50 & Target

EC50: 2.8 nM (TrxR)[1]

In Vitro

TrxR inhibitor D9 (0.1-1 μM; 72 h) inhibits the cell proliferation with IC50s of 0.03 and 0.1 μM for MCF-7 and HT-29 cells, respectively[1].
TrxR inhibitor D9 (72 h) completely inhibits all cancer cells (A549, KB, MDA MB-231, HeLa, MCF-7 and HT-29) viability at the concentration of 0.60 μM, and the IC50s of all cancer cells could be as low as 0.55 μM, and dose not significantly affects normal cells viability[1].
TrxR inhibitor D9 (0.8 μM; 4 and 8 h) induces HT-29 cells necrosis/apoptosis[1].
TrxR inhibitor D9 (2-20 nM; 1-60 s) inhibits TrxR activity in a concentration-dependent manner[1].
TrxR inhibitor D9 (1-1000 nM) does not significantly inhibits the catalytic activity of glutathione reductase (GR) even when the concentration increases to more than 1000 nM[1].
TrxR inhibitor D9 (0.4 μM) could effectively avoid the ligand exchange with albumin[1].

Cell Proliferation Assay[1]

Cell Line: MCF-7 and HT-29 cells
Concentration: 0.1, 0.5, 1 μM
Incubation Time: 72 hours
Result: Killed 70% MCF-7 cells and 50% HT-29 cells with the concentration as low as 0.1 μM.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0.8 μM
Incubation Time: 4 and 8 hours
Result: Led to more than 50% necrosis/apoptosis of cells compared to control after 4 h of treatment.
Induced all cells necrosis/apoptosis after 8 h of incubation.
In Vivo

TrxR inhibitor D9 (5 mg/kg; i.v. once every 2 d for 15 d) effectively inhibits the growth of tumors in mice[1].

Animal Model: BALB/c nude mice (17-18 g) bearing a MCF-7 tumor[1]
Dosage: 5 mg/kg
Administration: I.v. once every 2 days for 15 days
Result: Inhibited tumor growth with IR (inhibition ratio) of 91.5% and was well tolerated.
Molecular Weight

596.43

Formula

C₂₅H₂₀AuOPS

CAS No.

1527513-89-8

SMILES

COC1=CC=C(C=C1)C#[C-][Au+][P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CS4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TrxR inhibitor D9TrxR inhibitor D 9TrxR inhibitor D-9ApoptosisthioredoxinreductaseTrxRtumorcancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
TrxR inhibitor D9
目录号:
HY-136279
需求量: