1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin inhibitor 7

Tubulin inhibitor 7 

目录号: HY-136122
产品使用指南

Tubulin inhibitor 7 (Compound 33c) 是一种微管蛋白 (tubulin) 抑制剂,也是多种肿瘤细胞系的有效抑制剂。Tubulin inhibitor 7 抑制微管蛋白聚合,IC50 为 0.52 μM。Tubulin inhibitor 7 抑制 K562 细胞生长,IC50 为 11 nM。

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Tubulin inhibitor 7 Chemical Structure

Tubulin inhibitor 7 Chemical Structure

CAS No. : 1309925-41-4

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生物活性

Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].

IC50 & Target

IC50: 0.52 μM (tubulin polymerization)[1]

体外研究
(In Vitro)

Tubulin inhibitor 7 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1].
Tubulin inhibitor 7 shows excellent antiproliferative potencies with IC50s of 40, 24, 16, 6, 29, and 16 nM for NCIH460, SKOV3, BT549, 451LU, SW480, and DLD-1 tumor cell lines, recpectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

358.35

Formula

C₂₁H₁₄N₂O₄

CAS 号
SMILES

N#CC1=CC=C2N(C(C3=CC=C(OC)C(O)=C3)=O)C4=C(C=CC=C4)OC2=C1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

Keywords:

Tubulin inhibitor 7Tubulin inhibitor7Tubulin inhibitor-7Microtubule/TubulinAntiproliferativetubulincellcycleK562NCIH460SKOV3BT549451LUSW480COLO-205DLD-1Inhibitorinhibitorinhibit

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产品名称:
Tubulin inhibitor 7
目录号:
HY-136122
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