1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin inhibitor 8

Tubulin inhibitor 8 (Compound 33b) 是一种微管蛋白 (tubulin) 抑制剂,也是多种肿瘤细胞系的有效抑制剂。Tubulin inhibitor 8 抑制微管蛋白聚合,IC50 为 0.73 μM。Tubulin inhibitor 6 抑制 K562 细胞生长,IC50 为 14 nM。

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Tubulin inhibitor 8 Chemical Structure

Tubulin inhibitor 8 Chemical Structure

CAS No. : 1309925-39-0

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  • 生物活性

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生物活性

Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].

IC50 & Target

IC50: 0.73 μM (tubulin polymerization)[1]

体外研究
(In Vitro)

Tubulin inhibitor 8 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1].
Tubulin inhibitor 8 shows excellent antiproliferative potencies with IC50s of 15, 6, 8, 2, 8, 6, and 9 nM for NCIH460, SKOV3, BT549, 451LU, SW480, COLO-205, and DLD-1 tumor cell lines, recpectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

342.35

Formula

C21H14N2O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Tubulin inhibitor 8 相关分类

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Tubulin inhibitor 8
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HY-136123
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