1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin polymerization-IN-37

Tubulin polymerization-IN-37 是一种微管蛋白 (tubulin) 聚合抑制剂 (IC50: 2.3 μM)。Tubulin polymerization-IN-37 与微管蛋白的 colchicine 位点结合并抑制 colchicine 的结合。Tubulin polymerization-IN-37 可用于淋巴瘤等癌症的研究。

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Tubulin polymerization-IN-37 Chemical Structure

Tubulin polymerization-IN-37 Chemical Structure

CAS No. : 2011784-92-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1].

IC50 & Target

Tubulin polymerization[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
0.99 μM
Compound: 6k
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
M14 IC50
0.89 μM
Compound: 6k
Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
MCF-10A IC50
> 100 μM
Compound: 6k
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
MCF7 IC50
0.92 μM
Compound: 6k
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
MDA-MB-231 IC50
0.75 μM
Compound: 6k
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
PC-3 IC50
0.87 μM
Compound: 6k
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
WI-38 IC50
> 100 μM
Compound: 6k
Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
体外研究
(In Vitro)

Tubulin polymerization-IN-37 (compound 2f, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%[1].
Tubulin polymerization-IN-37 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells[1].
Tubulin polymerization-IN-37 (5 μΜ) inhibits colchicine binding to tubulin by 80%[1].
Tubulin polymerization-IN-37 shows cytotoxicity against MCF-7 cells (IC50: 0.21 μΜ)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells.
Concentration: 0-10 μΜ
Incubation Time: 72 h
Result: Inhibited cell proliferation to 28.1%, 8.6%, 7.3%, 13.8% at 1 μΜ, respectively. IC50s: 0.12, 0.07, 0.08, 0.07 μΜ, respectively.

Cell Cycle Analysis[1]

Cell Line: VL51 and MINO cells
Concentration: 50 and 500 nM
Incubation Time: 24, 48 and 72 h
Result: Arrested cell in G2/M phase.
分子量

340.37

Formula

C19H20N2O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tubulin polymerization-IN-37
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