2. Immunology/Inflammation
  3. CD3
  4. Ubamatamab

Ubamatamab  (Synonyms: REGN4018)

目录号: HY-P99539

摩尔计算器

Ubamatamab (REGN4018) 是一种靶向粘蛋白 16 (MUC16) 和 CD3 的人源化双特异性抗体。Ubamatamab 表现出有效的抗肿瘤活性。

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Ubamatamab Chemical Structure

Ubamatamab Chemical Structure

CAS No. : 2305629-50-7

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Ubamatamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity[1].

体外研究
(In Vitro)

Ubamatamab（REGN4018；0.1 pM-10 nM；48 小时）诱导人 T 细胞和猕猴 T 细胞杀死 OVCAR-3 细胞 (EC50 值分别为 13.6 pM 和 30.6 pM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ubamatamab 相关抗体:

Cell Viability Assay[1]

Cell Line: OVCAR-3 cells
Concentration: 0.1 pM-10 nM
Incubation Time: 48 hours
Result: Induced human T cells and cynomolgus T cells to kill OVCAR-3 cells.
体内研究
(In Vivo)

Ubamatamab（REGN4018；0.01-0.5 mg/kg；腹腔注射；第 6、10、13、16 和 21 天）有效抑制腹膜内卵巢肿瘤的生长[1]。
Ubamatamab（REGN4018；0.01-1 mg/kg；i.p；每周一次；总共五剂）显示血清细胞因子和 C 反应蛋白有轻微和短暂的增加，没有明显的毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells[1]
Dosage: 0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg
Administration: i.p; on days 6, 10, 13, 16, and 21
Result: Significantly reduced tumor burden, and did not result in any changes in weight.
Animal Model: Cynomolgus monkeys
Dosage: 0.01, 0.1, or 1 mg/kg
Administration: i.p; once a week; total of five doses
Result: Showed minimal and transient increases in serum cytokines and C-reactive protein.
Clinical Trial
CAS 号
中文名称

乌巴妥单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ubamatamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ubamatamab2305629-50-7REGN4018乌巴妥单抗REGN 4018REGN-4018CD3Cluster of differentiation 3MUC16antitumor activity,Inhibitorinhibitorinhibit

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