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  3. Uridine 5'-diphosphate sodium salt

Uridine 5'-diphosphate sodium salt  (Synonyms: 尿苷-5'-二磷酸钠盐)

目录号: HY-W010820
产品使用指南

Uridine 5'-diphosphate sodium salt 是一种有效的选择性 P2Y6 受体天然激动剂 (EC50=300 nM; pEC50=6.52),也是一种有效的 P2Y14 拮抗剂 (pEC50=7.28)。Uridine 5'-diphosphate sodium salt 是一种内源性代谢产物 (endogenous metabolite),可催化多种底物的葡糖醛酸糖化反应,可用于核酸生物合成 (RNA biosynthesis)。

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Uridine 5'-diphosphate sodium salt Chemical Structure

Uridine 5'-diphosphate sodium salt Chemical Structure

CAS No. : 21931-53-3

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Uridine 5'-diphosphate sodium salt 的其他形式现货产品:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: Primary microglia
Concentration: 100 μM
Incubation Time: For 15 min
Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.
Formula

C9H14N2O12P2.xNa

CAS 号
中文名称

尿苷-5'-二磷酸钠盐

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Uridine 5'-diphosphate sodium salt
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