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  3. Uridine 5'-diphosphate sodium salt

Uridine 5'-diphosphate sodium salt  (Synonyms: 尿苷-5'-二磷酸钠盐)

目录号: HY-W010820

Uridine 5'-diphosphate sodium salt 是一种有效的选择性 P2Y6 受体天然激动剂 (EC50=300 nM; pEC50=6.52),也是一种有效的 P2Y14 拮抗剂 (pEC50=7.28)。Uridine 5'-diphosphate sodium salt 是一种内源性代谢产物 (endogenous metabolite),可催化多种底物的葡糖醛酸糖化反应,可用于核酸生物合成 (RNA biosynthesis)。

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Uridine 5'-diphosphate sodium salt Chemical Structure

Uridine 5'-diphosphate sodium salt Chemical Structure

CAS No. : 21931-53-3

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Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

IC50 & Target[1]

Human Endogenous Metabolite


(In Vitro)

Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Cell Line: Primary microglia
Concentration: 100 μM
Incubation Time: For 15 min
Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.





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Uridine 5'-diphosphate sodium salt