1. Immunology/Inflammation
  2. Interleukin Related
  3. Vixarelimab

Vixarelimab  (Synonyms: KPL-716)

目录号: HY-P99519 纯度: ≥95.0%
COA

Vixarelimab (KPL-716) 是一种人源的抗 oncostatin M (OSM)单克隆抗体,可以与 OSM 受体的β链结合,抑制 IL-31 和 OSM 的信号传导。Vixarelimab 可用于特应性皮炎和结节性痒疹等皮肤炎症性疾病研究。

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Vixarelimab Chemical Structure

Vixarelimab Chemical Structure

CAS No. : 2243320-83-2

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1 mg ¥4500
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash[1].

体外研究
(In Vitro)

Vixarelimab (KPL-716) (0.0001-0.1 μg/mL) 在浓度为 0.0001 μg/mL 时,导致人表皮角质形成细胞 (HEK) 和人真皮成纤维细胞 (HDF) 的 MCP-1/CCL2 水平升高,当浓度为 0.001 μg/mL 或更高时,两种细胞的 MCP-1/CCL2 水平显著降低[1]
Vixarelimab (KPL-716) (0.0001-0.1 μg/mL) 预处理使得在 Oncostatin M(OSM)诱导的以及 OSM + IL-4 诱导的 HEK 和 HDF 细胞中,都降低了 MCP-1/CCL2 的水平,并且在浓度为 0.01 μg/mL 和 0.1 μg/mL 时观察到最大的效果[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: ≥95.0%

参考文献

Vixarelimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Vixarelimab
目录号:
HY-P99519
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