1. Protein Tyrosine Kinase/RTK
  2. FGFR
  3. Vofatamab

Vofatamab  (Synonyms: 沃凡妥单抗; B-701; MFGR-1877S; RG-7444)

目录号: HY-P99384 纯度: 98.32%
COA 技术支持

Vofatamab (B-701) 是一种抗 FGFR3 单克隆抗体 (mAb)。沃法塔玛可阻断野生型和基因激活型受体的激活。Vofatamab 可用于转移性尿路上皮癌 (mUC) 的研究。推荐同型对照:Human IgG1 kappa, Isotype Control (HY-P99001)。

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CAS No. : 1312305-12-6

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规格 价格 是否有货 数量
1 mg ¥3200
In-stock
5 mg ¥8000
In-stock
10 mg   询价  
50 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1].

同型

Human IgG1 kappa

推荐同型对照抗体
IC50 & Target[1]

FGFR3

 

体内研究
(In Vivo)

静脉注射后,Vofatamab 可特异性结合并抑制野生型和突变型 FGFR3。这可能抑制 FGFR3 磷酸化,从而阻止其活化和 FGFR3 介导的信号转导通路[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

146.44 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

沃凡妥单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human FGFR3 Protein (ECD,alpha IIIb, His Tag) can bind Vofatamab. The EC50 for this effect is 2.51 ng/mL.
纯度 & 产品资料

纯度: 98.32%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Vofatamab
目录号:
HY-P99384
需求量: