1. Membrane Transporter/Ion Channel
    Anti-infection
  2. Proton Pump
    Bacterial
  3. Vonoprazan hydrochloride

Vonoprazan hydrochloride (Synonyms: TAK-438 hydrochloride)

目录号: HY-100007A
产品使用指南

Vonoprazan hydrochloride 是一种质子泵抑制剂 (PPI),是高效的,具有口服活性的钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB),具有抗分泌活性。在 pH 为 6.5 时,Vonoprazan hydrochloride抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50 值为 19 nM。Vonoprazan hydrochloride 被开发用于研究胃酸相关疾病,如胃食管反流病和消化性溃疡。Vonoprazan hydrochloride 可用于根除幽门螺杆菌。

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Vonoprazan hydrochloride Chemical Structure

Vonoprazan hydrochloride Chemical Structure

CAS No. : 1957202-44-6

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Vonoprazan hydrochloride 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori[1][2][3].

IC50 & Target

IC50: 19 nM (porcine gastric H+,K+-ATPase, at pH 6.5)[2]

体外研究
(In Vitro)

Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H+, K+-ATPase activity in a concentration-dependent manner[2].
Vonoprazan does not inhibit Na+,K+-ATPase activity, even at concentrations 500 times higher than their IC50 values against gastric H+,K+-ATPase activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 7- or 8-week-old Sprague-Dawley rat[2]
Dosage: 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: Oral administration
Result: Inhibited basal gastric acid secretion in a dose-dependent manner.
分子量

381.85

Formula

C17H17ClFN3O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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目录号:
HY-100007A
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