2. Inhibitory Antibodies
  3. Vorsetuzumab

Vorsetuzumab  (Synonyms: Anti-Human CD70 Recombinant Antibody)

目录号: HY-P99273 纯度: 95.00%
COA

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Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) 是抗人 CD70 抗体。Vorsetuzumab 能够增强肾癌细胞巨噬相关吞噬作用，对Burkitt 淋巴瘤具有抑制作用。

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Vorsetuzumab Chemical Structure

Vorsetuzumab Chemical Structure

CAS No. : 1165740-62-4

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1 mg ￥2800
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5 mg ￥7200
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Vorsetuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma[1].

IC50 & Target

CD70[1]
体外研究
(In Vitro)

Vorsetuzumab (10 μg/mL; 2 h) augments macrophage-dependent phagocytosis of renal carcinoma cells in vitro[1].
Vorsetuzumab (10 μg/mL; 2 h) can be developed into bispecific anti-human CD70/KWAR23 antibody, results KWAR23 moderately induced macrophage phagocytosis of four renal carcinoma cell lines (RCC4, RCC10, TK10, and Caki-1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vorsetuzumab 相关抗体:
体内研究
(In Vivo)

Vorsetuzumab (10 mg/kg; i.p.; every other day; for 12 d) inhibits Burkitt’s lymphoma cell growth growth in SRG mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Burkitt’s lymphoma xenograft model in SRG mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; every other day; for 12 d
Result: Effectively inhibited Burkitt’s lymphoma cell growth but was not outperform the combination of the KWAR23 antibody (10 mg/kg).
分子量

146.1 (kDa)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vorsetuzumab1165740-62-4Anti-Human CD70 Recombinant AntibodyOthersTHP cellsBurkitt’s lymphomarenal carcinomamacrophagephagocytosisInhibitorinhibitorinhibit

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