2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. WF-536

WF-536 是一种 Rho 相关卷曲螺旋蛋白激酶 (ROCK) 抑制剂，具有口服活性。WF-536 具有肿瘤抗转移活性。WF-536 可用于癌症研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

WF-536 Chemical Structure

WF-536 Chemical Structure

CAS No. : 539857-64-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

WF-536 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

查看所有亚型
ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1].

体外研究
(In Vitro)

WF-536（1、3、10、30、100 μM）抑制 LLC 细胞的侵袭和迁移以及内皮细胞在 Matrigel 上的侵袭、迁移和毛细管样管的形成，在这两种细胞类型下均无细胞毒性或抗增殖作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WF-536 相关抗体:

Cell Migration Assay [1]

Cell Line: LLC cells, Human umbilical vein endothelial cells
Concentration: 1, 3, 10, 30 μM
Incubation Time: 6 h (tumor cells), 4 h (endothelial cells)
Result: Significantly inhibited LLC-cell migration, with inhibitory rates of 23% and 44% at 10 and 30 μM, respectively.

Cell Invasion Assay[1]

Cell Line: LLC cells, Human umbilical vein endothelial cells
Concentration: 1, 3, 10, 30 μM
Incubation Time: 18 h
Result: Showed significant and concentration-dependent inhibition of LLC-cell invasion.

Cell Proliferation Assay[1]

Cell Line: LLC cells, Human umbilical vein endothelial cells
Concentration: 1, 30, 100 μM
Incubation Time: 24, 48, 72, and 96 h
Result: Showed no significant effect at 1-30 μM on the proliferation up to 96 h incubation, although the proliferation was decreased at 100 μM over 48 h.
体内研究
(In Vivo)

WF-536（口服；0.3-3 mg/kg/天；持续 28 天）抑制小鼠 Lewis 肺癌 (LLC) 转移和 LLC 诱导的血管生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (male, 6-week old)[1]
Dosage: 0.3, 1, 3 mg/kg
Administration: Oral; daily; for 28 days
Result: Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg).
分子量

277.75

Formula

C14H16ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WF-536 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WF-536539857-64-2WF536WF 536ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKRho-associated coiled-coil-containing protein kinase (ROCK)tumor metastasisoralcancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
WF-536
目录号：
HY-118837
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z