WIN 64338 hydrochloride 

WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [³H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a K_i of 64 nM. WIN 64338 hydrochloride also can inhibits [³H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (K_i=350 nM)^[1][2].

Ki: 64 nM (bradykinin B2 receptor)^[1], 350 nM (muscarinic receptor)^[2]

WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated ⁴⁵Ca²⁺ efflux from IMR-90 cells (pA₂=7.1)^[1].
WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA₂=8.2)^[1].
WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a K_B of 64.3 nM^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WIN 64338 (5 mg/kg; i.p.) hydrochloride decreases the physiological anxiety measure, stress-induced hyperthermia (SIH) of mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

783.94

C₄₅H₆₉Cl₂N₄OP

163727-74-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sawutz DG, et, al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7.  [Content Brief]

  [2]. Scherrer D, et, al. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8.  [Content Brief]

  [3]. Rouhiaine A, et, al. The bradykinin system in stress and anxiety in humans and mice. Sci Rep. 2019 Dec 19;9(1):19437.  [Content Brief]