2. PROTAC Protein Tyrosine Kinase/RTK
  3. Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)
  4. WZH-15-125

WZH-15-125 是一种强效的 ALK 抑制剂。WZH-15-125 可有效地克服耐药性，特别是复合 ALK 突变。WZH-15-125 对 Lorlatinib (HY-12215) 耐药的高度难治性 G1202R/L1196M 突变的 IC50 为 101.7 nM。WZH-15-125 可作为 PROTAC 靶蛋白配体，合成 PROTAC WZH-17-002 (HY-174315)。WZH-15-125 能够用于非小细胞肺癌的研究。

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WZH-15-125 Chemical Structure

WZH-15-125 Chemical Structure

CAS No. : 2845188-22-7

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WZH-15-125 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WZH-15-125 is a potent ALK inhibitor. WZH-15-125 can effectively overcome drug resistance, especially compound ALK mutations. WZH-15-125 has an IC50 of 101.7 nM for the highly refractory G1202R/L1196M mutation that is resistant to Lorlatinib (HY-12215). WZH-15-125 can be used as a PROTAC target protein ligand to synthesize PROTAC WZH-17-002 (HY-174315). WZH-15-125 can be used in the research of non-small cell lung cancer[1].

分子量

745.73

Formula

C33H45BrN8O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WZH-15-125 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WZH-15-1252845188-22-7Ligands for Target Protein for PROTACAnaplastic lymphoma kinase (ALK)Target Protein-binding MoietyAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Ba/F3DFCI076H3122H2228PC9A549H460H157H292BEAS-2BMRC-5Inhibitorinhibitorinhibit

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