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  3. Xylopine

Xylopine  (Synonyms: 木番荔枝碱)

目录号: HY-N9534 纯度: ≥98.0%
COA 产品使用指南

Xylopine 是一种阿朴啡生物碱,对癌细胞具有细胞毒活性。Xylopine 诱导氧化应激,导致癌细胞的 G2/M 细胞周期停滞和细胞凋亡 (apoptosis)。

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Xylopine Chemical Structure

Xylopine Chemical Structure

CAS No. : 517-71-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells[1].

体外研究
(In Vitro)

Xylopine (3.5 μM-14 μM; 24-48 hours) displays potent cytotoxicity in a time- and does-depenpent manner[1].
Xylopine (72 h) has cytotoxic activity, with IC50 values ranging from 6.4 to 26.6 μM in eight different cancer cell lines (MCF7, HCT116, HepG2, SCC-9, HSC-3, HL-60, K-562, and B16-F10)[1].
Xylopine (3.5 μM-14 μM; 24-48 hours) causes cell cycle block at the phase G2/M, which is followed by internucleosomal DNA fragmentation[1].
Xylopine (3.5 μM-14 μM; 24-48 hours) significantly increases the early and late apoptosis, induces mitochondrial depolarization, and increases caspase-3 activation[1].
Xylopine also causes an increase in the production of reactive oxygen/nitrogen species (ROS/RNS), including hydrogen peroxide and nitric oxide, but not superoxide anion, and reduces glutathione levels are decreased in Xylopine-treated HCT116 cells[1]. HCT116 cells[1] 3.5 μM, 7 μM, and 14 μM 24 hours, 48 hours Induced G2/M phase arrest. HCT116 cells[1] 3.5 μM, 7 μM, and 14 μM 24 hours, 48 hours Significantly increased the early and late apoptosis.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Displayed potent cytotoxicity in HCT116 cells.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Induced G2/M phase arrest.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Significantly increased the early and late apoptosis.
分子量

295.33

Formula

C18H17NO3

CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

木番荔枝碱

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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