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  3. yGsy2p-IN-H23

yGsy2p-IN-H23 

目录号: HY-131062
产品使用指南

yGsy2p-IN-H23 是一种有效的酵母糖原合酶 2 (yGsy2p) 抑制剂,对人糖原合酶 1 (hGYS1) 的 IC50 为 875 µM。yGsy2p-IN-H23 结合在 yGsy2p 的尿苷二磷酸葡萄糖结合口袋内。yGsy2p-IN-H23 用于糖原储存疾病 (GSDs)。

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yGsy2p-IN-H23 Chemical Structure

yGsy2p-IN-H23 Chemical Structure

CAS No. : 1269190-98-8

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Description

yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for glycogen storage diseases (GSDs)[1].

IC50 & Target

IC50: 875 µM (hGYS1)[1]

In Vitro

yGsy2p-IN-H23 (H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 of 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].

Molecular Weight

377.48

Formula

C₂₃H₂₇N₃O₂

CAS No.

1269190-98-8

SMILES

OC1=CC=C(C2=C(C3=CC=CC=C3)N=CN2CCC4N(C)CCC4)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

yGsy2p-IN-H23Othersfirst-in-classyeastglycogensynthase2yGsy2phumanhGYS1uridinediphosphatestoragediseasesGSDsInhibitorinhibitorinhibit

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产品名称:
yGsy2p-IN-H23
目录号:
HY-131062
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