2. Cell Cycle/DNA Damage
  3. CDK
  4. YJZ5118

YJZ5118 是一种 CDK12/13 抑制剂，对抑制 CDK12 和 CDK13 的 IC50 值分别为 39.5 nM 和 26.4 nM。YJZ5118 可通过诱导 DNA 损伤和细胞凋亡 (Apoptosis)，抑制肿瘤细胞增殖，与 Akt 抑制剂有协同效应。YJZ5118 可用于癌症领域的研究。

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YJZ5118

YJZ5118 Chemical Structure

CAS No. : 3031861-18-1

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YJZ5118 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YJZ5118 is a CDK12/13 inhibitor with IC50 values of 39.5 nM and 26.4 nM against CDK12 and CDK13, respectively. By inducing DNA damage and Apoptosis, YJZ5118 effectively suppresses tumor cell proliferation and exhibits synergistic effects with Akt inhibitors. YJZ5118 can be used for research in the field of cancer[1].

IC50 & Target

CDK12

 

CDK13

 

分子量

620.79

Formula

C36H44N8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YJZ5118 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YJZ51183031861-18-1YJZ 5118YJZ-5118CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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产品名称：
YJZ5118
目录号：
HY-173273
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