2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. (Z)-Lafutidine

(Z)-Lafutidine  (Synonyms: (Z)-FRG-8813)

目录号: HY-121406
产品使用指南

摩尔计算器

(Z)-Lafutidine ((Z)-FRG-8813) 是一种通过感觉传入神经元发挥粘膜保护作用的组胺 H2 受体拮抗剂，具有抗分泌和胃保护活性。

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(Z)-Lafutidine Chemical Structure

(Z)-Lafutidine Chemical Structure

CAS No. : 206449-93-6

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Other Forms of (Z)-Lafutidine:

(Z)-Lafutidine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities[1].

体内研究
(In Vivo)

(Z)-Lafutidine (Compound 16) stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight- to nine-week-old male C57BL/6 mice weighing 20-24g[1]
Dosage: 3-30 mg/kg
Administration: P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily)
Result: Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg.
分子量

431.55

Formula

C22H29N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Z)-Lafutidine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

(Z)-Lafutidine206449-93-6(Z)-FRG-8813Histamine ReceptorsensoryafferentneuronsmucosalprotectivegastrointestinalInhibitorinhibitorinhibit

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