2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. β-Endorphin (6-31), human

β-Endorphin (6-31), human  (Synonyms: β-EP (6-31), human)

目录号: HY-P3517
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摩尔计算器

β-Endorphin，一种内源性阿片类神经肽，是一种阿片受体 (opioid receptor) 激动剂。β-Endorphin 优先与 μ-阿片受体结合，在中枢和周围神经系统的某些神经元中产生，是人类产生的三种内啡肽之一。β-Endorphin 可以用于减轻压力和维持体内平衡，参与神经系统疼痛感知的调节。

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Custom Peptide Synthesis

β-Endorphin (6-31), human Chemical Structure

β-Endorphin (6-31), human Chemical Structure

CAS No. : 77761-27-4

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β-Endorphin (6-31), human 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation[1].

体内研究
(In Vivo)

β-Endorphin (0.03 to 1.00 μg/kg, i.p., once) impairs retention of a one-trial inhibitory avoidance task in a dose-dependent manner in male Swiss mice immediately post-training. Also, it works in the process of memory consolidation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Swiss mice (22-25 g)[1]
Dosage: 0.03, 0.10, 0.30 or 1.00 μg/kg
Administration: i.p., once
Result: Significantly impaired retention at the doses of 0.03 and 0.10 μg/kg while not significantly affect retention as compared with the control group at the two higher doses of 0.30 and 1.00 μg/kg , but tended to increase retention as compared with the dose of 0.10 μg/kg.
Increased latencies to step-through at the two higher doses of 0.30 and 1.00 μg/kg but no effect at lower doses.
分子量

2909.38

Formula

C131H218N34O40
CAS 号
Sequence

Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
Sequence Shortening

TSEKSQTPLVTLFKNAIIKNAYKKGE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Endorphin (6-31), human 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Endorphin (6-31), human77761-27-4β-EP (6-31), humanOpioid Receptoropioid neuropeptideopioid receptorreduce stresshomeostasispain perception regulationInhibitorinhibitorinhibit

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