1. Stem Cell/Wnt
  2. Wnt
  3. WNT7A-IN-1 sodium

WNT7A-IN-1 sodium (1365-0109) 是一种 WNT7A 抑制剂,可破坏 WNT7A 与其受体 FZD5 之间的蛋白质-蛋白质相互作用,从而上调 MHC-I 表达。WNT7A-IN-1 sodium 显著增加 MHC-I 和 p-p65 的表达,同时降低活性 β-catenin 的表达。WNT7A-IN-1 sodium (compound F) 也是绿色光谱区域的感光增感剂。

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WNT7A-IN-1 sodium Chemical Structure

WNT7A-IN-1 sodium Chemical Structure

CAS No. : 33628-03-4

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生物活性

WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin[1]. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region[2].

IC50 & Target

Wnt7A

 

分子量

722.80

Formula

C37H35N2NaO8S2

CAS 号
性状

固体

颜色

Orange to red

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
WNT7A-IN-1 sodium
目录号:
HY-D1474
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