5-Aminouridine 

5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses^[1][2][3].

This modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy)₃³⁺. These modified nucleobases can be inserted into the target DNA by direct synthesis using modified phosphoramidites^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-Aminouridine inhibits incorporation of carbamylaspartate into pyrimidines of both RNA and DNA in rat lived and [³²P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

259.22

C₉H₁₃N₃O₆

2149-76-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Smith DA, et al. Studies on 5-aminouridine. Biochim Biophys Acta. 1966 May 19;119(2):221-8.  [Content Brief]

  [2]. ROBERTS M, et al. Antimetabolite activity of uridine and cytidine derivatives. J Biol Chem. 1952 Feb;194(2):695-701. PMID: 14927662.. . .  [Content Brief]

  [3]. ROBERTS M, et al. Antimetabolite activity of uridine and cytidine derivatives. J Biol Chem. 1952 Feb;194(2):695-701.

  [4]. MR, et al. Detection of attomole quantities [correction of quantitites] of DNA targets on gold microelectrodes by electrocatalytic nucleobase oxidation. Anal Chem. 2003 Dec 1;75(23):6586-92.  [Content Brief]