2. Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Lipoxygenase Interleukin Related TNF Receptor IFNAR
  4. 5-LOX-IN-8

5-LOX-IN-8 是一种具有抗炎活性的 5-LOX 抑制剂。5-LOX-IN-8 可抑制巨噬细胞中的 IL-6、IL-1β、TNF-α 和 IFN-γ，并降低 SW480 细胞中的 IL-8 分泌。5-LOX-IN-8 可降低 DSS 结肠炎模型中的疾病活动指数。5-LOX-IN-8 可用于炎症性肠病 (IBD) 的研究。

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5-LOX-IN-8 Chemical Structure

5-LOX-IN-8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

5-LOX-IN-8 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD)[1].

IC50 & Target[1]

5-LOX

 

IL-6

 

IL-1β

 

IL-8

 

体外研究
(In Vitro)

5-LOX-IN-8 (Compound 18d) (0.3-50 μM，24 小时) 对 THP-1 细胞 (IC50: 37.65 μM) 和 SW 480 细胞 (IC50: 14.37 μM) 均表现出细胞毒性[1]。
5-LOX-IN-8 (10 μM，5 分钟 ) 可抑制人重组 5-LOX 40.65%，同时可抑制 SW480 细胞中 NO 生成 38.85%[1]。
5-LOX-IN-8 (10 μM，预处理 1 小时，然后与 LPS 共培养 24 小时) 可抑制 LPS (HY-D1056) 刺激的 THP-1 巨噬细胞中 IL-6 (93.98%)、IL-1β (19.41%) 和 TNF-α (45.97%) 和 IFN-γ (66.61%) 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-LOX-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: THP-1 cell, SW 480 cell
Concentration: 0.3-50 μM
Incubation Time: 24 h
Result: Inhibited the cell viability of THP-1 cell (IC50: 37.65 μM) and SW 480 cell (IC50: 14.37 μM).
And the cell viability of THP-1 cell and SW 480 cell at 50 μM were 65.54% and 56.23%, respectively.
体内研究
(In Vivo)

5-LOX-IN-8 (Compound 18d) (30 mg/kg) 可降低 5% DSS (HY-116282C) 诱导的小鼠结肠炎模型中的疾病活动性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5% DSS (v/v, in drinking water, every second day) murine colitis model
Dosage: 30 mg/kg
Administration:
Result: Increased the body weight (87.84%) compared with DSS-treated group (73.75%).
Slightly increased the colon length (mm) compared with DSS-treated group.
Significantly reduced DAI from Day-4 to Day-7, with a Day-7 DAI of 8.67 compared to 11.67 for the DSS-treated group.
分子量

478.58

Formula

C29H34O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-LOX-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-LOX-IN-8LipoxygenaseInterleukin RelatedTNF ReceptorIFNARLOXILTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptoranti-inflammatoryIL-6IL-1βTNF-αIFN-γmacrophagesDSScolitisinflammatory bowel diseaseIBDInhibitorinhibitorinhibit

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