Brincidofovir (Synonyms: CMX001; HDP-CDV)

目录号: HY-14532 纯度: 99.46%: Data Sheet SDS COA 产品使用指南
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Brincidofovir (CMX001) 是 Cidofovir (HY-17438) 的脂质结合前体药物，是一种口服、长效抗病毒剂。Brincidofovir 对广泛的 DNA 病毒具有活性，包括巨细胞病毒 (CMV)、腺病毒 (ADV)、水痘带状疱疹病毒、单纯疱疹病毒、多瘤病毒、乳头瘤病毒、痘病毒和混合双链 DNA 病毒感染。Brincidofovir是一种具有口服活性的抗病毒化合物，已被证明在体外和体内对正痘病毒有效。

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Brincidofovir Chemical Structure

CAS No. : 444805-28-1

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规格	价格	是否有货
1 mg	￥960	In-stock
5 mg	￥2240	In-stock
10 mg	￥3360	In-stock
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Customer Review

Other Forms of Brincidofovir:

Brincidofovir-d₆ 询价

MCE 顾客使用本产品发表的 2 篇科研文献

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HSV-1 HSV-2 HSV

生物活性
纯度 & 产品资料
参考文献

生物活性

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo^[1]^[2]^[3]^[4].

IC₅₀ & Target

EC50: 5.5 nM (anti-CMV, in PDA at 7 dpi)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
BSC-1	EC₅₀	0.125 μM Compound: 1, HDP-CDV	Antiviral activity against Ectromelia virus Moscow infected in african green monkey BSC1 cells after 4 to 5 days by plaque reduction assay Antiviral activity against Ectromelia virus Moscow infected in african green monkey BSC1 cells after 4 to 5 days by plaque reduction assay	[PMID: 21493074]
BSC-1	CC₅₀	25.3 μM Compound: 1, HDP-CDV	Cytotoxicity against african green monkey BSC1 cells after 2 to 4 hrs by MTS assay Cytotoxicity against african green monkey BSC1 cells after 2 to 4 hrs by MTS assay	[PMID: 21493074]
HFF	EC₅₀	0.08 μM Compound: 1, HDP-CDV	Antiviral activity against Vaccinia virus Copenhagen infected in human HFF cells after 3 days by plaque reduction assay Antiviral activity against Vaccinia virus Copenhagen infected in human HFF cells after 3 days by plaque reduction assay	[PMID: 21493074]
HFF	EC₅₀	0.13 μM Compound: CMX001	Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction plaque formation after 3 days Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction plaque formation after 3 days	[PMID: 17724153]
HFF	EC₅₀	0.14 μM Compound: CMX001	Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction plaque formation after 3 days Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction plaque formation after 3 days	[PMID: 17724153]
HFF	EC₅₀	0.2 μM Compound: 1, HDP-CDV	Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells after 3 days by plaque reduction assay Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells after 3 days by plaque reduction assay	[PMID: 21493074]
HFF	EC₅₀	0.24 μM Compound: CMX001	Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction plaque formation after 3 days Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction plaque formation after 3 days	[PMID: 17724153]
HFF	EC₅₀	0.6 μM Compound: HDP-CDV	Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction of viral replication after 3 days Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction of viral replication after 3 days	[PMID: 17846137]
HFF	EC₅₀	0.8 μM Compound: HDP-CDV	Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction of viral replication after 3 days Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction of viral replication after 3 days	[PMID: 17846137]
HFF	EC₅₀	1.1 μM Compound: HDP-CDV	Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction of viral replication after 3 days Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction of viral replication after 3 days	[PMID: 17846137]
HFF	CC₅₀	25 μM Compound: 1, HDP-CDV	Cytotoxicity against human HFF cells assessed as reduction in cell viability after 7 days by neutral red uptake assay Cytotoxicity against human HFF cells assessed as reduction in cell viability after 7 days by neutral red uptake assay	[PMID: 21493074]
HFF	CC₅₀	31 μM Compound: HDP-CDV	Cytotoxicity against HFF cells after 7 days Cytotoxicity against HFF cells after 7 days	[PMID: 17846137]
HFF	CC₅₀	42 μM Compound: CMX001	Cytotoxicity against HFF cells after 7 days by neutral red assay Cytotoxicity against HFF cells after 7 days by neutral red assay	[PMID: 17724153]

体内研究
(In Vivo)

Brincidofovir (BCV) (20 mg/kg；口服；在第 1、3、5、7、10、14、17、21 和 24 天) 延长 IHD-J-Luc VACV 处理的免疫缺陷 BALB/c nu/nu 小鼠的存活期^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nu/nu mice (infected with IHD-J-Luc VACV)^[3]
Dosage:	20 mg/kg
Administration:	P.o.; on days 1, 3, 5, 7, 10, 14, 17, 21, and 24
Result:	On days 1, 3, and 5 maintained their weights initially but started to lose weight beginning on day 9 and succumbed between days 24 and 29 postchallenge.

Clinical Trial

分子量

561.69

Formula

C₂₇H₅₂N₃O₇P

CAS 号

444805-28-1

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

0.1 M NaOH 中的溶解度 : 50 mg/mL (89.02 mM; 超声助溶)

DMSO 中的溶解度 : 1 mg/mL (1.78 mM; adjust pH to 8 with NaOH and heat to 50°C; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7803 mL	8.9017 mL	17.8034 mL
5 mM	0.3561 mL	1.7803 mL	3.5607 mL
10 mM	0.1780 mL	0.8902 mL	1.7803 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.46%

选择批次：

Data Sheet (608 KB) SDS (393 KB)

COA (278 KB) HNMR (283 KB) CNMR (207 KB) RP-HPLC (270 KB) MS (69 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Hiwarkar P, et al. Brincidofovir is highly efficacious in controlling adenoviremia in pediatric recipients of hematopoietic cell transplant. Blood. 2017;129(14):2033-2037. [Content Brief]

[2]. Detweiler CJ, et al. Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD. J Pediatr Hematol Oncol. 2018;40(6):e364-e368. [Content Brief]

[3]. Zaitseva M, McCullough KT, Cruz S, et al. Postchallenge administration of brincidofovir protects healthy and immune-deficient mice reconstituted with limited numbers of T cells from lethal challenge with IHD-J-Luc vaccinia virus. J Virol. 2015;89(6):3295-3307. [Content Brief]

[4]. Scott A Foster , et al. The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak. Viruses. 2017 Oct 30;9(11):320. [Content Brief]

Brincidofovir 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO / 0.1 M NaOH	1 mM	1.7803 mL	8.9017 mL	17.8034 mL	44.5085 mL
0.1 M NaOH	5 mM	0.3561 mL	1.7803 mL	3.5607 mL	8.9017 mL
	10 mM	0.1780 mL	0.8902 mL	1.7803 mL	4.4509 mL
	15 mM	0.1187 mL	0.5934 mL	1.1869 mL	2.9672 mL
	20 mM	0.0890 mL	0.4451 mL	0.8902 mL	2.2254 mL
	25 mM	0.0712 mL	0.3561 mL	0.7121 mL	1.7803 mL
	30 mM	0.0593 mL	0.2967 mL	0.5934 mL	1.4836 mL
	40 mM	0.0445 mL	0.2225 mL	0.4451 mL	1.1127 mL
	50 mM	0.0356 mL	0.1780 mL	0.3561 mL	0.8902 mL
	60 mM	0.0297 mL	0.1484 mL	0.2967 mL	0.7418 mL
	80 mM	0.0223 mL	0.1113 mL	0.2225 mL	0.5564 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Brincidofovir (Synonyms: CMX001; HDP-CDV)

Customer Review

Other Forms of Brincidofovir:

MCE 顾客使用本产品发表的 2 篇科研文献