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Ethylenediaminetetraacetic acid trisodium salt  (Synonyms: 依地酸三钠盐; EDTA trisodium salt; Trisodium EDTA)

目录号: HY-B1009 纯度: ≥98.0%
COA 产品使用指南

Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) 是一种金属螯合剂 (与包括钙在内的二价和三价金属阳离子结合)。Ethylenediaminetetraacetic acid trisodium salt 具有抗菌、抗炎、抗氧化、抗高钙血症和抗凝血活性。Ethylenediaminetetraacetic acid trisodium salt 可减少金属离子催化的蛋白质氧化损伤,并维持蛋白质纯化过程中的还原环境,常用作蛋白质的纯化和储存。Ethylenediaminetetraacetic acid trisodium salt 能够缓解肝脏的纤维化。Ethylenediaminetetraacetic acid trisodium salt 可以用于冠状动脉疾病和神经系统疾病的研究。

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Ethylenediaminetetraacetic acid trisodium salt Chemical Structure

Ethylenediaminetetraacetic acid trisodium salt Chemical Structure

CAS No. : 150-38-9

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10 mM * 1 mL in Water ¥330
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

体外研究
(In Vitro)

Ethylenediaminetetraacetic acid 对铜绿假单胞菌 (P. aeruginosa) 和粪单胞菌 (a. faecalis) 的细胞壁具有较强的杀菌作用[4]
Ethylenediaminetetraacetic acid (0.005-0.01 M) 在污染粉质粘壤土土柱中具有较好的重金属萃取作用, 能以浓度依赖的方式萃取出 Pb、 Cd 和 Zn,萃取效率顺序为 Pb > Cd > Zn[6]
Ethylenediaminetetraacetic acid (1.2 mM) 在 HEK293T 细胞中通过激活 t 细胞死亡相关基因 8 (TDAG8) 来增强 CRE 驱动启动子的活性,从而增强了细胞中 cAMP 的产生[7]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ethylenediaminetetraacetic acid (60 mg/kg; 腹腔注射; 每周三次连续三周 ) 在 CCl4 诱导的肝纤维化大鼠中可以降低肝的纤维化、脂质过氧化和肝脏炎症,具有抗氧化和抗炎活性[5]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
Reduced fibrosis of the liver in surviving rats (20%).
Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
Clinical Trial
分子量

358.19

Formula

C10H13N2Na3O8

CAS 号
性状

固体

颜色

White to off-white

中文名称

依地酸三钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (139.59 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7918 mL 13.9591 mL 27.9181 mL
5 mM 0.5584 mL 2.7918 mL 5.5836 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 50 mg/mL (139.59 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Ethylenediaminetetraacetic acid trisodium salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7918 mL 13.9591 mL 27.9181 mL 69.7954 mL
5 mM 0.5584 mL 2.7918 mL 5.5836 mL 13.9591 mL
10 mM 0.2792 mL 1.3959 mL 2.7918 mL 6.9795 mL
15 mM 0.1861 mL 0.9306 mL 1.8612 mL 4.6530 mL
20 mM 0.1396 mL 0.6980 mL 1.3959 mL 3.4898 mL
25 mM 0.1117 mL 0.5584 mL 1.1167 mL 2.7918 mL
30 mM 0.0931 mL 0.4653 mL 0.9306 mL 2.3265 mL
40 mM 0.0698 mL 0.3490 mL 0.6980 mL 1.7449 mL
50 mM 0.0558 mL 0.2792 mL 0.5584 mL 1.3959 mL
60 mM 0.0465 mL 0.2327 mL 0.4653 mL 1.1633 mL
80 mM 0.0349 mL 0.1745 mL 0.3490 mL 0.8724 mL
100 mM 0.0279 mL 0.1396 mL 0.2792 mL 0.6980 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ethylenediaminetetraacetic acid trisodium salt
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